Synergistic effect of lipoprotein (a) and C-reactive protein on prognosis of familial hypercholesterolemia.

ABSTRACT:

Objective

The synergistic effect of lipoprotein (a) [Lp(a)] and C-reactive protein (CRP) on major adverse cardiovascular events (MACE) among patients with familial hypercholesterolemia (FH) is unknown. This study aimed to investigate the relations between Lp(a) and CRP levels and MACE in patients with FH whose Lp(a) levels are elevated.

Methods

We retrospectively investigated associations between genotypes and phenotypes, including low-density lipoprotein (LDL) cholesterol level and the occurrence of MACE among patients with FH (N = 786, male/female: 374/412). A Cox proportional hazard model was used to identify factors associated with MACE, adjusting for traditional risk factors. Patients with FH were divided into four groups, based on their Lp(a) and CRP levels, and assess

SUBMITTER: Tada H 

PROVIDER: S-EPMC9661434 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature