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ABSTRACT:
SUBMITTER: Preti B
PROVIDER: S-EPMC9661479 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Preti Barbara B Suchankova Anna A Deganutti Giuseppe G Leuenberger Michele M Barkan Kerry K Manulak Iga I Huang Xianglin X Carvalho Sabrina S Ladds Graham G Lochner Martin M
Journal of medicinal chemistry 20221021 21
A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists <i>N</i><sup>6</sup>-cyclopentyl adenosine (CPA) and <i>N</i><sup>6</sup>-cyclopentyl 5'-<i>N</i>-ethylcarboxamidoadenosine (CP-NECA) were synthesized, and their potency and selectivity were assessed. We observed that the most potent were the compounds with a halogen in the <i>meta</i> position on the aromatic ring of the benzyloxy- or phenoxycyclopentyl substituent. In general, the NECA-based compounds displayed gr ...[more]