Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults.

ABSTRACT:

Background

Hypertension-mediated organ damage (HMOD) is an emerging problem among young adults. The potential role of chronic immune-mediated inflammation in the pathogenesis of HMOD is increasingly being recognized. High-mobility group box 2 (HMGB2) is known for its role in the modulation of innate immunity and exerts signaling functions that affect various inflammatory diseases. However, the association between HMGB2 and HMOD in young adults remains unclear.

Objectives

The aim of this study was to explore the association between HMGB2 and subclinical HMOD in young adults.

Design

This is a cross-sectional study.

Methods

Body composition, carotid ultrasound, carotid-femoral PWV (cf-PWV) measures, echocardiography, serum HMGB2 levels, and serum classic cardiomet

SUBMITTER: Wan J 

PROVIDER: S-EPMC9661567 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature