Body mass index across adulthood and the development of airflow obstruction and emphysema.

ABSTRACT:

Background

Low body mass index (BMI) is associated with COPD, but temporal relationships between airflow obstruction (AO) development and emphysematous change are unclear. We investigated longitudinal changes in BMI, AO, and lung density throughout adulthood using data from the Framingham Offspring Cohort (FOC).

Methods

BMI trajectories were modelled throughout adulthood in 4587 FOC participants from Exam 2 (mean age = 44), through Exam 9 (mean age = 71), in AO participants and non-AO participants (AO n = 1036), determined by spirometry, using fractional polynomial growth curves. This process was repeated for low lung density (LLD) and non LLD participants (LLD n = 225) determined by Computed Tomography. Spirometry decline was compared separately between tertil

SUBMITTER: Trethewey RE 

PROVIDER: S-EPMC9661572 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature