Printer center nanoparticles alter the DNA repair capacity of human bronchial airway epithelial cells.

ABSTRACT: Nano-enabled, toner-based printing equipment emit nanoparticles during operation. The bioactivity of these nanoparticles as documented in a plethora of published toxicological studies raises concerns about their potential health effects. These include pro-inflammatory effects that can lead to adverse epigenetic alterations and cardiovascular disorders in rats. At the same time, their potential to alter DNA repair pathways at realistic doses remains unclear. In this study, size-fractionated, airborne particles from a printer center in Singapore were sampled and characterized. The PM_0.1 size fraction (particles with an aerodynamic diameter less than 100 nm) of printer center particles (PCP) were then administered to human lung adenocarcinoma (Calu-3) or lymphoblastoid (TK6) cells.

SUBMITTER: Bitounis D 

PROVIDER: S-EPMC9661631 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature