Sustained release of hydrogen sulfide from anisotropic ferrofluid hydrogel for the repair of spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) results in massive neuronal death, axonal disruption, and cascading inflammatory response, which causes further damage to impaired neurons. The survived neurons with damaged function fail to form effective neuronal circuits. It is mainly caused by the neuroinflammatory microenvironment at injury sites and regenerated axons without guidance. To address this challenge, a ferrofluid hydrogel (FFH) was prepared with Ferric tetrasulfide (Fe₃S₄), carboxymethyl chitosan, and gold. Its internal structural particles can be oriented in a magnetic field to acquire anisotropy. Moreover, Fe₃S₄ can release hydrogen sulfide (H₂S) with anti-inflammatory effects under acidic conditions. Regarding in vitro experiments, 0.

SUBMITTER: Wang R 

PROVIDER: S-EPMC9661652 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature