Design and synthesis of some novel triazine-tyrosine hybrids as potential agents for the treatment of multiple sclerosis.

ABSTRACT:

Background and purpose

One of the most noteworthy methods to slow down multiple sclerosis (MS) progress is a decrease of lymphocyte cells via S1P1 receptor modulating. Here, a series of S1P1 receptor modulators were designed and investigated for their ability to decrease lymphocytes in a rat model.

Experimental approach

Molecular docking was performed to compare the binding mode of desired compounds 5a-f with fingolimod to the active site of the S1P1 receptor, theoretically. To prepare desired compounds, 5a-f, cyanuric chloride was reacted with different amines, a-f, which then converted to 4a-f compounds through reaction with N-boc-Tyr-OMe ester. Finally, deprotection of the carboxyl and amino groups was carried out to obtain 5a-f a

SUBMITTER: Saeidi S 

PROVIDER: S-EPMC9661688 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature