Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis.

ABSTRACT:

Background

Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes, but evidence from large human cohorts is lacking. This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations.

Methods

We included 1430 participants from the Guangzhou Nutrition and Health Study (GNHS) with both gut microbiome and cognitive assessment data available as a discovery cohort, of whom 272 individuals provided fecal samples twice before cognitive assessment. We selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up visit. Fecal 16S rRNA and shotgun meta

SUBMITTER: Liang X 

PROVIDER: S-EPMC9661756 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature