Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events.

ABSTRACT:

Background

Aggressive lipid lowering by high-dose statin treatment has been established for the secondary prevention of coronary artery disease (CAD). Regarding the low-density lipoprotein cholesterol (LDL-C) level, however, the "The lower is the better" concept has been controversial to date. We hypothesized that there is an optimal LDL-C level, i.e., a "threshold" value, below which the incidence of cardiovascular events is no longer reduced. We undertook a subanalysis of the REAL-CAD study to explore whether such an optimal target LDL-C level exists by a novel analysis procedure to verify the existence of a monotonic relationship.

Methods

For a total of 11,105 patients with CAD enrolled in the REAL-CAD study, the LDL-C level at 6 months after randomization and 5-year card

SUBMITTER: Sakuma M 

PROVIDER: S-EPMC9661797 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature