Differential Oral Microbial Input Determines Two Microbiota Pneumo-Types Associated with Health Status.

ABSTRACT: The oral and upper respiratory tracts are closely linked anatomically and physiologically with the lower respiratory tract and lungs, and the influence of oral and upper respiratory microbes on the lung microbiota is increasingly being recognized. However, the ecological process and individual heterogeneity of the oral and upper respiratory tract microbes shaping the lung microbiota remain unclear owing to the lack of controlled analyses with sufficient sample sizes. Here, the microbiomes of saliva, nasal cavity, oropharyngeal area, and bronchoalveolar lavage samples are profiled and the shaping process of multisource microbes on the lung microbiota is measured. It is found that oral and nasal microbial inputs jointly shape the lung microbiota by occupying different ecological niches. It i

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9661847 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature