Mass cytometry analysis reveals attrition of naive and anergized self-reactive non-malignant B cells in chronic lymphocytic leukemia patients.

ABSTRACT: Chronic Lymphocytic Leukemia (CLL) is characterized by the progressive accumulation of monoclonal mature B lymphocytes. Autoimmune complications are common in CLL occurring in up to a quarter of all patients during the course of the illness. Etiology of autoimmunity in CLL is unknown but it is widely admitted that the pathogenic auto-Abs do not originate from the tumoral clone but from the non-malignant B cell pool. This indicates that the developmental scheme of non-malignant B cells could also be perturbed in CLL patients. To address this question, we have designed a B cell-centered antibody panel and used time-of-flight mass cytometry to compare the residual non-malignant B cell pool of CLL patients with the peripheral B cell pool of age-matched healthy donors. We show that the non-mali

SUBMITTER: Andrieu T 

PROVIDER: S-EPMC9661965 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature