Extracellular vesicles metabolic changes reveals plasma signature in stage-dependent diabetic kidney disease.

ABSTRACT:

Objective

Early diagnosis of diabetic kidney disease (DKD) has long been a complex problem. This study aimed to analyze the metabolomic characteristics of plasma extracellular vesicles (EVs) at different stages of DKD in order to evaluate the metabolites of plasma EVs and select new biomarkers for the early diagnosis of DKD.

Patients and methods

A total of 78 plasma samples were collected, including samples from 20 healthy controls, 20 patients with type 2 diabetes mellitus (T2DM), 18 patients with DKD stage III, and 20 patients with DKD stage IV. In addition, EVs were isolated for metabolomics analysis.

Results

The results identified differences in EV metabolomic characteristics in DKD patients at different stages, as well as significant differences in EV metabolomic

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9662026 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature