A potential novel inflammation biomarker for predicting the prognosis of decompensated liver cirrhosis.

ABSTRACT:

Objective

This study aimed to explore the prognostic value of the lymphocyte (LYM)-to-white blood cell (WBC) ratio (LWR) in patients with decompensated liver cirrhosis (DLC).

Methods

This study was conducted by recruiting 214 patients with DLC with different aetiologies (development cohort). Receiver operating characteristic (ROC) curve analyses were used to assess the predictive accuracy of the LWR, and Youden's index was used to determine the optimal cut-off values of the LWR based on the ROC curve. Next, patients were divided into high- and low-LWR groups according to the cut-off values. Multivariate logistic analyses were performed to determine the independent predictors for the 1-, 3- and 6-month mortality. Restricted cubic spline (RCS) was used to determine and visuali

SUBMITTER: Xie Y 

PROVIDER: S-EPMC9662056 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature