Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer.

ABSTRACT:

Background

Screening for colorectal cancer (CRC) reduces its mortality but has limited sensitivity and specificity. Aims We aimed to explore potential biomarker panels for CRC and adenoma detection and to gain insight into the interaction between gut microbiota and human metabolism in the presence of these lesions.

Methods

This multicenter case-control cohort was performed between February 2016 and November 2019. Consecutive patients ≥18 years with a scheduled colonoscopy were asked to participate and divided into three age, gender, body-mass index and smoking status-matched subgroups: CRC (n = 12), adenomas (n = 21) and controls (n = 20). Participants collected fecal samples prior to bowel preparation on which proteome (LC-MS/MS), microbiota (16S rRNA profiling) and amino a

SUBMITTER: Bosch S 

PROVIDER: S-EPMC9662191 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature