Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron.

ABSTRACT: Hypertension is characterized by increased sodium (Na⁺) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this inflammatory process. Interestingly, increased Na⁺ reabsorption within the ASDN does not always correlate with increases in aldosterone (Aldo), the primary hormone that modulates Na⁺ reabsorption via the mineralocorticoid receptor (MR). Thus, understanding how increased ASDN Na⁺ reabsorption may occur independent of Aldo stimulation is critical. Here, we show that IL-6 can activate the MR by activating Rac1 and stimulating the generation of reactive oxygen species (ROS) with a consequent increase in thiazide-sensitive Na^+</

SUBMITTER: Wynne BM 

PROVIDER: S-EPMC9662807 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature