VCAM-1-targeted MRI Improves Detection of the Tumor-brain Interface.

ABSTRACT:

Purpose

Despite optimal local therapy, tumor cell invasion into normal brain parenchyma frequently results in recurrence in patients with solid tumors. The aim of this study was to determine whether microvascular inflammation can be targeted to better delineate the tumor-brain interface through vascular cell adhesion molecule-1 (VCAM-1)-targeted MRI.

Experimental design

Intracerebral xenograft rat models of MDA231Br-GFP (breast cancer) brain metastasis and U87MG (glioblastoma) were used to histologically examine the tumor-brain interface and to test the efficacy of VCAM-1-targeted MRI in detecting this region. Human biopsy samples of the brain metastasis and glioblastoma margins were examined for endothelial VCAM-1 expression.

Results

The interface between tumor and s

SUBMITTER: Cheng VWT 

PROVIDER: S-EPMC9662863 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature