Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers.

ABSTRACT: The somatic landscape of the cancer genome results from different mutational processes represented by distinct "mutational signatures." Although several mutagenic mechanisms are known to cause specific mutational signatures in cell lines, the variation of somatic mutational activities in patients, which is mostly attributed to somatic selection, is still poorly explained. Here, we introduce a quantitative trait, mutational propensity (MP), and describe an integrated method to infer genetic determinants of variations in the mutational processes in 3,566 cancers with specific underlying mechanisms. As a result, we report 2,314 candidate determinants with both significant germline and somatic effects on somatic selection of mutational processes, of which, 485 act via cancer gene expression an

SUBMITTER: Guo J 

PROVIDER: S-EPMC9662923 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature