Integrated Bioinformatics-Based Identification of Ferroptosis-Related Genes in Carotid Atherosclerosis.

ABSTRACT:

Background

Ferroptosis, a type of cell death caused by phospholipid peroxidation, has lately been linked to the onset and development of numerous illnesses. Numerous investigations have demonstrated the close relationship between lipid peroxidation and carotid atherosclerosis. In order to get new knowledge for targeted therapy, bioinformatics analysis was employed in this study to discover the probable ferroptosis-related genes of carotid atherosclerosis.

Methods

The GSE43292 gene expression dataset was downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed ferroptosis-related genes were screened by R software and then analyzed by protein-protein interaction (PPI) network, differential gene correlation analysis, Kyoto Encyclopedia of Gene an

SUBMITTER: Wei L 

PROVIDER: S-EPMC9663224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature