Gut bacteriome and metabolome of Ascaris lumbricoides in patients.

ABSTRACT: The most frequent intestinal helminth infections in humans are attributed to Ascaris lumbricoides, and there are concerns over the anthelminthic resistance of this species. The gut microbiota has essential roles in host physiology. Therefore, discovering host-parasite-microbiota interactions could help develop alternative helminthiasis treatments. Additionally, these interactions are modulated by functional metabolites that can reveal the mechanisms of infection and disease progression. Thus, we aimed to investigate bacteriomes in the gut of helminths and fecal samples of patients via next-generation sequencing. Our results showed that infection intensity was associated with the bacterial composition of helminth guts but not with the intestinal bacteriome of human hosts. Moreover, the meta

SUBMITTER: Klomkliew P 

PROVIDER: S-EPMC9663418 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature