Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting.

ABSTRACT: Adipose tissue loss seen with cancer-associated cachexia (CAC) may functionally drive cachexia development. Using single-cell transcriptomics, we unveil a large-scale comprehensive cellular census of the stromal vascular fraction of white adipose tissues from patients with or without CAC. We report depot- and disease-specific clusters and developmental trajectories of adipose progenitors and immune cells. In adipose tissues with CAC, clear pro-inflammatory transitions were discovered in adipose progenitors, macrophages and CD8⁺ T cells, with dramatically remodeled cell interactome among these cells, implicating a synergistic effect in promoting tissue inflammation. Remarkably, activated CD8⁺ T cells contributed specifically to increased IFNG expression in adipose tiss

SUBMITTER: Han J 

PROVIDER: S-EPMC9663454 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature