Sodium alginate-hydrogel coatings on extracorporeal membrane oxygenation for anticoagulation.

ABSTRACT: Thromboembolism caused by the use of extracorporeal membrane oxygenation (ECMO) remains common among patients with existing heart diseases and contributes to significant morbidity and mortality during the COVID-19 pandemic. Various surface modification strategies have been proposed, showing that the methacrylated alginate (MA-SA) hydrogel layer is transparent, which aids the observation of the thromboembolism from the inner wall of the tubing. In the combined dynamic and static blood of ECMO tubing inner surface in vitro experiments, it was also demonstrated that the adhesion of blood clots to the surface of vessels was remarkably reduced, and the MA-SA-based hydrogel coating could significantly prolong the activated partial thrombin time and block the endogenous coagulation. The fa

SUBMITTER: Gao W 

PROVIDER: S-EPMC9663475 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature