DUSP1 promotes muscle atrophy by inhibiting myocyte differentiation in cachectic patients.

ABSTRACT:

Background

Skeletal muscle atrophy is the major hallmark of cancer cachexia. The mechanisms underlying muscle wasting remain elusive in cachectic patients. Our research seeks to identify differentially expressed genes (DEGs) between non-cachectic and cachectic cancer patients and elucidate their functions.

Methods

We screened the DEGs of skeletal muscle between patients with and without cachexia from microarray data. Biological function of DEGs is analyzed through gene enrichment analysis, while an interaction network is constructed to visualize how genes are related. A Spearman's correlation analysis demonstrated the clinical significance of DUSP1 related to cancer cachexia. Skeletal muscle samples were collected and histomorphology studies were conducted. Function of DUSP1

SUBMITTER: Sui X 

PROVIDER: S-EPMC9663480 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature