Reproductive risk factors associated with breast cancer in young women by molecular subtype.

ABSTRACT:

Background

Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention.

Methods

We surveyed parous enrollees in the prospective Mayo Clinic Breast Disease Registry (MCBDR) who had been diagnosed with BC at age <55 years between 2015 and 2020. Summary statistics were used to describe survey responses and reproductive risk factors by BC subtype (defined by estrogen/progesterone receptors and human epidermal growth factor receptor expression, nurse-abstracted from the medical record). Associations were assessed with Kruskal-Wallis and Chi-Square tests, followed by age-adjusted linear and logistic regress

SUBMITTER: Ruddy KJ 

PROVIDER: S-EPMC9663520 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature