Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.

ABSTRACT: The cerebellar network is renowned for its regular architecture that has inspired foundational computational theories. However, the relationship between circuit structure, function and dynamics remains elusive. To tackle the issue, we developed an advanced computational modeling framework that allows us to reconstruct and simulate the structure and function of the mouse cerebellar cortex using morphologically realistic multi-compartmental neuron models. The cerebellar connectome is generated through appropriate connection rules, unifying a collection of scattered experimental data into a coherent construct and providing a new model-based ground-truth about circuit organization. Naturalistic background and sensory-burst stimulation are used for functional validation against recordings in vi

SUBMITTER: De Schepper R 

PROVIDER: S-EPMC9663576 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature