Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC9663691 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Li Zheng Z Yue Muxin M Heng Boon Chin BC Liu Yunsong Y Zhang Ping P Zhou Yongsheng Y
International journal of oral science 20221115 1
As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase (PCK2) has further complex functions beyond regulation of glucose metabolism. Here, we report that conditional knockout of Pck2 in osteoblasts results in a pathological phenotype manifested as craniofacial malformation, long bone loss, and marrow adipocyte accumulation. Ablation of Pck2 alters the metabolic pathways of developing bone, particularly fatty acid metabolism. However, metformin treatment can m ...[more]