Ontology highlight
ABSTRACT:
SUBMITTER: Foster WS
PROVIDER: S-EPMC9663747 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Foster William S WS Lee Jia Le JL Thakur Nazia N Newman Joseph J Spencer Alexandra J AJ Davies Sophie S Woods Danielle D Godfrey Leila L Hay Iain M IM Innocentin Silvia S Yam-Puc Juan Carlos JC Horner Emily C EC Sharpe Hayley J HJ Thaventhiran James E JE Bailey Dalan D Lambe Teresa T Linterman Michelle A MA
Cell reports. Medicine 20221115 12
Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines generate high-affinity plasma blasts and long-lived protective memory B cells. Here, we show a requirement for T follicular helper (Tfh) cells and the germinal center reaction for optimal serum antibody and memory B cell formation after ChAdOx1 nCoV-19 vaccination. We found that Tfh cells play an important role in expanding antige ...[more]