The Role of Angiopoietins in Neovascular Diabetes-Related Retinal Diseases.

ABSTRACT: Diabetic retinopathy is a devastating and frequent complication of poorly controlled diabetes, whose pathogenesis is still only partially understood. Advances in basic research over the last two decades have led to the discovery of angiopoietins, proteins that strongly influence the growth and integrity of blood vessels in many vascular beds, with particular importance in the retina. Angiopoietin 1 (Ang1), produced mostly by pericytes and platelets, and angiopoietin 2 (Ang2), produced mainly by endothelial cells, bind to the same receptor (Tie2), but exert opposing effects on target cells. Ang1 maintains the stability of the mature vasculature, while Ang2 promotes vessel wall destabilization and disruption of the connections between endothelial cells and pericytes. Human retinal endothelia

SUBMITTER: Collazos-Aleman JD 

PROVIDER: S-EPMC9663771 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature