Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease.

ABSTRACT:

Background

Gastro-oesophageal reflux disease (GORD) is a common gastrointestinal dysfunction that significantly affects the quality of daily life, and health interventions are challenging to prevent the risk of GORD. In this study, we used Mendelian randomization framework to genetically determine the causal associations between multifaceted modifiable factors and the risk of GORD.

Materials and methods

Sixty-six exposures with available instrumental variables (IVs) across 6 modifiable pathways were included in the univariable MR analysis (UVMR). Summary-level genome-wide association studies (GWAS) datasets for GORD were retrieved from the Neale Lab (GORD _Neale , Ncases = 29975, Ncontrols = 390556) and FinnGen (GORD _Finn , Ncases = 13141,

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9663808 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature