Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples.

ABSTRACT: Schizophrenia (SCZ) and major depressive disorder (MDD) are complex psychiatric disorders which contribute substantially to the global burden of disease. Both psychopathologies are heritable with some genetic overlap between them. Importantly, SCZ and MDD have also been found to be associated with environmental risk factors. However, rather than being independent of genetic influences, exposure to environmental risk factors may be under genetic control, known as gene-environment correlation (rGE). In this study we investigated rGE in relation to polygenic risk scores for SCZ and MDD in adults, derived from large genome-wide association studies, across two different British community samples: Understanding Society (USoc) and the National Child Development Study (NCDS). We tested whether est

SUBMITTER: Machlitt-Northen S 

PROVIDER: S-EPMC9663827 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature