Alternation of the gut microbiota in metabolically healthy obesity: An integrated multiomics analysis.

ABSTRACT:

Background

Although the gut microbiota may be involved in obesity onset and progression, the exact association of the gut microbiota in metabolically healthy obesity (MHO) remains largely unknown.

Methods

An integrated paired-sample metagenomic analysis was conducted to investigate the gut microbial network and biomarkers of microbial species from the MHO and healthy non-obese subjects in the GMrepo database. Further explorations were performed in the MHO mice model using a multiomics analysis to detect changes in the composition and function of the intestinal microbiome and associated metabolites.

Results

In the human study, 314 matched metagenomic data were qualified for the final analysis. We identified seven significantly changed species possibly involved in MHO p

SUBMITTER: Chen H 

PROVIDER: S-EPMC9663839 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature