Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections.

ABSTRACT: Siglecs are a family of emerging glyco-immune checkpoints. Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modulating immunological functions during cancer, however, their roles in regulating immunological equilibrium during viral infections is less clear. In this review, we discuss the documented and potential roles of inhibitory Siglecs in balancing immune activation and tolerance during viral infections and consider how this balance could affect both the desired anti-viral immunological functions and the unwanted hyper- or chronic inflammation. Finally, we discuss the opportunities to target the Siglec immunol

SUBMITTER: Saini P 

PROVIDER: S-EPMC9663867 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature