TMEM158 expression is negatively regulated by AR signaling and associated with favorite survival outcomes in prostate cancers.

ABSTRACT:

Background

Membrane protein TMEM158 was initially reported as a Ras-induced gene during senescence and has been implicated as either an oncogenic factor or tumor suppressor, depending on tumor types. It is unknown if TMEM158 expression is altered in prostate cancers.

Methods

Multiple public gene expression datasets from RNA-seq and cDNA microarray assays were utilized to analyze candidate gene expression profiles. TMEM158 protein expression was assessed using an immunohistochemistry approach on a tissue section array from benign and malignant prostate tissues. Comparisons of gene expression profiles were conducted using the bioinformatics software R package.

Results

COX regression-based screening identified the membrane protein TMEM158 gene as negatively associated wi

SUBMITTER: Huang J 

PROVIDER: S-EPMC9663988 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature