Intratumoral injection of holmium-166 microspheres as neoadjuvant therapy of soft tissue sarcomas in dogs.

ABSTRACT:

Introduction

Minimally invasive microbrachytherapy is in development to treat solid tumors by intratumoral injection of (radioactive) holmium-166 (¹⁶⁶Ho) microspheres (MS). A high local dose can be administered with minimal damage to surrounding tissue because of the short soft tissue penetration depth of ¹⁶⁶Ho beta radiation. We aimed to prospectively evaluate the safety and efficacy of ¹⁶⁶Ho microbrachytherapy in client-owned canine patients with soft tissue sarcomas (STS).

Methods

We included seven dogs with STS not suitable for local excision due to tumor size and/or location. ¹⁶⁶HoMS were suspended in a carrier fluid and multiple needle-injections were performed in predetermined tumor segments to maximize tumor coverage. Tumor

SUBMITTER: Morsink NC 

PROVIDER: S-EPMC9664058 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature