Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation.

ABSTRACT:

Background

Obesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index (BMI), left atrial (LA) fibrosis and volume.

Methods

LA fibrosis and EAT were assessed using late gadolinium enhancement, and Dixon MRI sequences, respectively. We derived 3D models incorporating fibrosis and EAT, then measured the distance of fibrotic and non-fibrotic areas to the nearest EAT to assess spatial colocalization.

Results

One hundred and three AF patients (64% paroxysmal, 27% female) were analyzed. LA volume index was 54.9 (41.2, 69.7) mL/m², LA EAT

SUBMITTER: Chahine Y 

PROVIDER: S-EPMC9664066 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature