An in vitro whole-cell electrophysiology dataset of human cortical neurons.

ABSTRACT:

Background

Whole-cell patch-clamp electrophysiology is an essential technique for understanding how single neurons translate their diverse inputs into a functional output. The relative inaccessibility of live human cortical neurons for experimental manipulation has made it difficult to determine the unique features of how human cortical neurons differ from their counterparts in other species.

Findings

We present a curated repository of whole-cell patch-clamp recordings from surgically resected human cortical tissue, encompassing 118 neurons from 35 individuals (age range, 21-59 years; 17 male, 18 female). Recorded human cortical neurons derive from layers 2 and 3 (L2&3), deep layer 3 (L3c), or layer 5 (L5) and are annotated with a rich set of subject and experimental metadat

SUBMITTER: Howard D 

PROVIDER: S-EPMC9664072 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature