Drug repurposing as a potential source of innovative therapies in cervical cancer.

ABSTRACT:

Objective

Drug repurposing is an alternative development pathway that utilizes the properties of drugs approved for other diseases and builds on available safety and pharmacological data to develop the drug as a potential treatment for other diseases. A literature-based approach was performed to identify drug repurposing opportunities in cervical cancer to inform future research and trials.

Methods

We queried PubMed for each drug included in two databases (ReDO_DB and CDcervix_DB, which include 300+ non-cancer drugs and 200+ cancer drugs not used in cervical cancer, respectively) and manually assessed all abstracts for relevance and activity in cervix cancer, and type of evidence. Subsequently, we also performed a search of clinical trial databases where we generated a list

SUBMITTER: Capistrano I R 

PROVIDER: S-EPMC9664115 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature