Osteoclast activity sculpts craniofacial form to permit sensorineural patterning in the zebrafish skull.

ABSTRACT: Efforts to understand the morphogenesis of complex craniofacial structures have largely focused on the role of chondrocytes and osteoblasts. Along with these bone-creating cells, bone-resorbing osteoclasts are critical in homeostasis of adult skeletal structures, but there is currently limited information on their role in the complex morphogenetic events of craniofacial development. Fundamental aspects of skull formation and general skeletal development are conserved from zebrafish to mammals. Using a cathepsinK reporter, we documented osteoclast location in the developing zebrafish skull over several weeks, from 5.18 mm to 9.6 mm standard length (approximately 15 to 34 days post fertilization). While broad distribution of osteoclasts is consistent across individuals, they are spars

SUBMITTER: Miao KZ 

PROVIDER: S-EPMC9664155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature