Increased monocyte abundance as a marker for relapse after discontinuation of biologics in inflammatory bowel disease with deep remission.

ABSTRACT: Monocytes are involved in the upstream inflammatory process in the immune reaction in inflammatory bowel disease (IBD). Patients with IBD who discontinued biologics have been found to relapse, even after checking for deep remission. This study investigated whether monocytes could act as a predictor of relapse in patients who experienced relapse after the discontinuation of biologics. To this end, pediatric patients (<19 years old, n = 727) diagnosed with IBD from January 2003 to December 2021 were retrospectively reviewed. Clinical features, monocytes, and disease activity at the time of discontinuing biologics were evaluated by dividing patients into a relapsed group and a non-relapsed group after discontinuing biologics. The percentage of monocytes (8.65% vs. 6.42%, P < 0.001), the absol

SUBMITTER: Kwon Y 

PROVIDER: S-EPMC9664214 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature