Association between cause of kidney failure and fracture incidence in a national US dialysis population cohort study.

ABSTRACT:

Background

Whether fracture rates, overall and by fracture site, vary by cause of kidney failure in patients receiving dialysis is unknown.

Methods

Using the US Renal Data System, we compared fracture rates across seven causes of kidney failure in patients who started dialysis between 1997 and 2014. We computed unadjusted and multivariable adjusted proportional sub-distribution hazard models, with fracture events (overall, and by site) as the outcome and immunoglobulin A nephropathy as the reference group. Kidney transplantation and death were competing events.

Results

Among 491 496 individuals, with a median follow-up of 2.0 (25%, 75% range 0.9-3.9) years, 62 954 (12.8%) experienced at least one fracture. Patients with diabetic nephropathy, vasculitis or autosomal po

SUBMITTER: Ziolkowski S 

PROVIDER: S-EPMC9664571 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature