Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging and is associated with comorbid conditions including osteoporosis and sarcopenia. These extrapulmonary conditions are highly prevalent yet frequently underdiagnosed and overlooked by pulmonologists in COPD treatment and management. There is evidence supporting a role for bone-muscle crosstalk which may compound osteoporosis and sarcopenia risk in COPD. Chest CT is commonly utilized in COPD management, and we evaluated its utility to identify low bone mineral density (BMD) and reduced pectoralis muscle area (PMA) as surrogates for osteoporosis and sarcopenia. We then tested whether BMD and PMA were associated with morbidity and mortality in COPD.

Methods

BMD and PMA were analyzed from ch

SUBMITTER: Wilson AC 

PROVIDER: S-EPMC9664607 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature