Erenumab versus topiramate: post hoc efficacy analysis from the HER-MES study.

ABSTRACT:

Objective

HER-MES was the first head-to-head, phase 4 trial to assess the tolerability and effectiveness of erenumab against standard of care treatment (topiramate). This post hoc analysis compared the efficacy of erenumab with topiramate in patients who completed the trial on study medication.

Methods

Post hoc sensitivity analysis was performed using the full analysis set. Outcomes assessed included the proportion of patients with a ≥50% reduction in monthly migraine days (MMD) from baseline (50% responder rate), over the last 3 months (months 4, 5, and 6) of the double-blind treatment phase (DBTP), the 50% responder rate during the first month of the DBTP, and change from baseline in MMD during the DBTP. Multiple imputation was done for efficacy values of patients who disc

SUBMITTER: Ehrlich M 

PROVIDER: S-EPMC9664641 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature