Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections.

ABSTRACT:

Background

To understand how Plasmodium falciparum malaria is controlled, it is essential to elucidate the transcriptomic responses of the human host in naturally-exposed populations. Various individual studies of the human transcriptomic responses to naturally transmitted P. falciparum infections have been reported with varying results. Multicohort gene expression analysis by aggregating data from diverse populations into a single analysis will increase the reproducibility and reliability of the results.

Methods

In this study, discovery cohorts GSE1124-GPL96, GSE34404, GSE117613, and validation cohort GSE35858 were obtained from the Gene Expression Omnibus. A meta-analysis using data from the multicohort studies was performed to identify the differentially expressed genes (

SUBMITTER: Zhang YH 

PROVIDER: S-EPMC9664782 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature