Dataset Information

Effects of General Anesthesia on Changes of Serum Hepatitis B Virus-DNA Levels in Infected Patients Underwent Non-Hepatobiliary Minimally Invasive Surgery: A Pilot Observational Study.

ABSTRACT:

Objective

To investigate the effects of different general anesthesia methods on the changes of serum hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels in the hepatitis B virus (HBV) infected patients.

Methods

This pilot prospective observational study was carried out from March 2021 to January 2022. Forty patients infected by HBV, who underwent non-hepatobiliary minimally invasive surgery, were allocated into an intravenous anesthesia group maintained with propofol (Group P, n = 20) and an inhalation anesthesia group maintained with sevoflurane (Group S, n = 20) by a random envelope method. Patient's blood was drawn before operation (T_baseline), at 24 hours (T_{post 24hrs}) and 48 hours (T_{post 48hrs}) after operation to detect the serum HBV-DNA levels and analyze the subset levels of T, B lymphocytes and NK cells (TBNK) in two groups. The serum HBV-DNA level was used as the major outcome, and it was analyzed by repeated-measures analysis of variance after natural logarithm transformation.

Results

In Group P and Group S, compared with the baseline, the serum HBV-DNA levels decreased significantly at T_{post 24hrs} and T_{post 48hrs}, P<0.05. The total ratio of CD4⁺T cells and the ratio of CD4⁺T to CD8⁺T cells (CD4⁺/CD8⁺) were lower at T_{post 24hrs}, P<0.05, and the total ratio of B cells was significantly increased at T_{post 24hrs}, P<0.05. Compared with the values at T_{post 24hrs}, the total ratio of CD4⁺ T cells, CD4⁺/CD8⁺ T cells, and the total ratio of B cells were significantly increased at T_{post 48hrs} in both groups, P<0.05. However, there were no statistical differences between Group P and Group S.

Conclusion

The levels of serum HBV-DNA decreased within 48 hours after general anesthesia. There were no significant differences between the effects of intravenous and inhalation anesthesia on the serum HBV-DNA levels.

Trial registration

This study has been prospectively registered in the Clinical Trials Registry (NCT02038088, 1/28/2015).

SUBMITTER: Quan J

PROVIDER: S-EPMC9664914 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Effects of General Anesthesia on Changes of Serum Hepatitis B Virus-DNA Levels in Infected Patients Underwent Non-Hepatobiliary Minimally Invasive Surgery: A Pilot Observational Study.

Quan Junxian J Chen Xingtong X Chen Xingtong X Tang Xi X Liu Xianzhe X Li Jieyu J Yi Bin B Li Peng P Lu Kaizhi K Gu Jianteng J

Infection and drug resistance 20221111

<h4>Objective</h4>To investigate the effects of different general anesthesia methods on the changes of serum hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels in the hepatitis B virus (HBV) infected patients.<h4>Methods</h4>This pilot prospective observational study was carried out from March 2021 to January 2022. Forty patients infected by HBV, who underwent non-hepatobiliary minimally invasive surgery, were allocated into an intravenous anesthesia group maintained with propofol (Group P ...[more]

PMID: 36386418

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Dataset Information

Effects of General Anesthesia on Changes of Serum Hepatitis B Virus-DNA Levels in Infected Patients Underwent Non-Hepatobiliary Minimally Invasive Surgery: A Pilot Observational Study.

Objective

Methods

Results

Conclusion

Trial registration

Publications

Effects of General Anesthesia on Changes of Serum Hepatitis B Virus-DNA Levels in Infected Patients Underwent Non-Hepatobiliary Minimally Invasive Surgery: A Pilot Observational Study.

Similar Datasets

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