Photoactive Yellow Protein Represents a Distinct, Evolutionarily Novel Family of PAS Domains.

ABSTRACT: Photoactive yellow protein (PYP) is a model photoreceptor. It binds a p-coumaric acid as a chromophore, thus enabling blue light sensing. The first discovered single-domain PYP from Halorhodospira halophila has been studied thoroughly in terms of its structural dynamics and photochemical properties. However, the evolutionary origins and biological role of PYP homologs are not well understood. Here, we show that PYP is an evolutionarily novel domain family of the ubiquitous PAS (Per-Arnt-Sim) superfamily. It likely originated from the phylum Myxococcota and was then horizontally transferred to representatives of a few other bacterial phyla. We show that PYP is associated with signal transduction either by domain fusion or by genome context. Key cellular fu

SUBMITTER: Xing J 

PROVIDER: S-EPMC9664959 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature