Efficacy and toxicity with radiation field designs and concurrent temozolomide for CNS lymphoma.

ABSTRACT:

Background

There is no consensus on the treatment of central nervous system (CNS) lymphoma refractory to first-line methotrexate-based chemotherapy. Whole brain radiotherapy (WBRT) is sometimes used but may result in unacceptable neurocognitive dysfunction. We examined the efficacy and toxicities of WBRT with or without concurrent temozolomide in CNS lymphoma treatment.

Methods

This single-institution IRB-approved retrospective study included adults with CNS lymphoma who received WBRT, either consolidative low-dose WBRT alone or low-dose WBRT with a focal boost to residual disease and were previously treated with high-dose methotrexate. The relationships between the WBRT regimen, concurrent temozolomide, and clinical outcomes and toxicities were assessed using proportional h

SUBMITTER: Laucis AM 

PROVIDER: S-EPMC9665068 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature