Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

ABSTRACT:

Context

Veratramine may have a potential therapeutic effect for diabetic peripheral neuropathy (DPN).

Objective

To evaluate whether veratramine ameliorates neuropathic pain in a rat diabetic model.

Materials and methods

Sprague-Dawley rats were used for a diabetic model induced by a streptozotocin + high-fat diet. Two months after the induction of the diabetic model, the rats with DPN were screened according to the mechanical pain threshold. The rats with DPN were divided into a model group (n = 12) and a treated group (n = 12). Rats with diabetes, but without peripheral neuropathy, were used in the vehicle group (n = 9). The treatment group received 50 μg/kg veratramine via the tail vein once a day for 4 weeks. During modelling and treatment, rats in all three groups

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9665081 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature