Decrease in serum levels of autotaxin in COVID-19 patients.

ABSTRACT:

Introduction

In order to identify therapeutic targets in Coronavirus disease 2019 (COVID-19), it is important to identify molecules involved in the biological responses that are modulated in COVID-19. Lysophosphatidic acids (LPAs) are involved in the pulmonary inflammation and fibrosis are one of the candidate molecules. The aim of this study was to evaluate the association between the serum levels of autotaxin (ATX), which are enzymes involved in the synthesis of lysophosphatidic acids.

Material and methods

We enrolled 134 subjects with COVID-19 and 58 normal healthy subjects for the study. We measured serum ATX levels longitudinally in COVID-19 patients and investigated the time course and the association with severity and clinical parameters.

Results

The serum ATX

SUBMITTER: Shimura T 

PROVIDER: S-EPMC9665086 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature