Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population.

ABSTRACT: Prenatal lead (Pb) exposure is associated with adverse developmental outcomes and to epigenetic alterations such as DNA methylation and hydroxymethylation in animal models and in newborn blood. Given the importance of the placenta in foetal development, we sought to examine how prenatal Pb exposure was associated with differential placental DNA methylation and hydroxymethylation and to identify affected biological pathways linked to developmental outcomes. Maternal (n = 167) and infant (n = 172) toenail and placenta (n = 115) samples for prenatal Pb exposure were obtained from participants in a US birth cohort, and methylation and hydroxymethylation data were quantified using the Illumina Infinium MethylationEPIC BeadChip. An epigenome-wide association study was applied to identify differe

SUBMITTER: Tung PW 

PROVIDER: S-EPMC9665158 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature