Younger age is associated with greater early neurocognitive decline postcardiopulmonary bypass.

ABSTRACT:

Objective

To examine the effect of aging on postoperative neurocognitive decline (NCD) in cardiac surgery patients.

Methods

Patients undergoing coronary artery bypass graft or open aortic valve replacement were administered the Repeatable Battery for the Assessment of Neuropsychological Status at preoperative, postoperative day (POD) 4, and 1 month. Blood samples were collected at preoperative, 6 hours postoperative, and POD 4. Plasma interleukin (IL)-6, tumor necrosis factor-α, and C-reactive protein (CRP) levels were quantified. Quality of life was measured with the 12-Item Short Form Health Survey. Data were analyzed using paired ratio and unpaired t tests with Welch's correction, and linear regression for cytokine levels.

Results

NCD occurred in 15 patients

SUBMITTER: Anderson K 

PROVIDER: S-EPMC9665169 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature