Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling.

ABSTRACT: Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease pathogenesis. β-catenin is a key effector in this pathway that translocates into the nucleus and activates Wnt responsive genes. However, due to our lack of understanding of β-catenin nuclear transport, therapeutic modulation of Wnt signaling has been challenging. Here, we took an unconventional approach to address this long-standing question by exploiting a heterologous model system, the budding yeast Saccharomyces cerevisiae, which contains a conserved nuclear transport machinery. In contrast to prior work, we demonstrate that β-catenin accu

SUBMITTER: Hwang WY 

PROVIDER: S-EPMC9665845 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature